Mechanism of Differential Inhibition of Factor-Dependent Cell Proliferation by Transforming Growth Factor-pl: Selective Uncoupling of F M S From MYC
نویسندگان
چکیده
Transforming growth factor-81 (TGF-81 ) selectively modulates hematopoietic cell proliferation. The proliferation of FDC-P1 clone MAC-I 1, a factor-dependent murine myeloid progenitor cell line, was inhibited differentially by TGF-81 : strongly in macrophage colony-stimulating factor (M-CSF), mildly in interleukin-3, and not at all in granulocyte-macrophage-CSF (GM-CSF). Flow cytometry and Western blots showed an unexpected increase in expression of FMS, the receptor for M-CSF, in response to TGF-81. Metabolic labeling with j5S-methionine showed that synthesis of FMS protein accelerated in response to TGF-81 , whereas its degradation was unaffected. Northern analyses showed a
منابع مشابه
Mechanism of differential inhibition of factor-dependent cell proliferation by transforming growth factor-beta 1: selective uncoupling of FMS from MYC.
Transforming growth factor-beta 1 (TGF-beta 1) selectively modulates hematopoietic cell proliferation. The proliferation of FDC-P1 clone MAC-11, a factor-dependent murine myeloid progenitor cell line, was inhibited differentially by TGF-beta 1: strongly in macrophage colony-stimulating factor (M-CSF), mildly in interleukin-3, and not at all in granulocyte-macrophage-CSF (GM-CSF). Flow cytometry...
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